1 - H304 Environmental hazards Not Classified Classification (67/548/EEC or 1999/45/EC) F;R11 Repr. GHS Hazard Statements: H301 (10.17%): Toxic if swallowed [Danger Acute toxicity, oral]H302 (22.03%): Harmful if swallowed [Warning Acute toxicity, oral]H312 (16.95%): Harmful in contact with skin [Warning Acute toxicity, dermal]H314 (16.95%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H315 (79.66%): Causes skin irritation [Warning Skin corrosion/irritation] Toluene is also highly flammable and may catch on fire if … Toluene is an acute and long-term environmental hazard that can remain in soil and bodies of water for several days. Use only in well-ventilated areas. According to OSHA, it’s often used in a mixture with other solvents and chemicals, such as paint pigments, so employees who work with paint, metal cleaners and … Toluene Poisoning is the accidental or intentional intake of any product containing the compound. Closed containers … Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. NFPA Hazard ID: Health: 2 Flammability: 3 Reactivity: 0 HMIS Hazard ID: Health: 2* Flammability: 3 Reactivity: 0 … Toluene has been said to increase the risk of spontaneous abortions as well, though it’s been said that many other chemicals may have a hand in this. Mother’s exposure to toluene vapors during pregnancy may cause developmental damage in the fetus. Related Pages. LOA is currently reviewing the human and animal data supporting Human Health for Toluene. Vapour may accumulate in hazardous amounts in low-lying areas especially inside confined spaces, resulting in a toxicity hazard. Your use of this website indicates your agreement to these terms and those published here. Tightly covering them when not in use is equally important. Truth Publishing International, LTD. is not responsible for content written by contributing authors. Safety Data Sheet (Toluene… Columbus, WI. *7l�Fy��A~���Iv�)�AN��f:ژ9�ߝ�|�Lah3.��~f�3��/_;uӱ���j�=��gO������5����c�㸼����}r��d�v���~@�uf���y^�_�I��&W�YG�T �����p.�p���|�2���i���@f�DFC=rk0� -��\m�!�L1���J;&٠��^�8�[KJ!��JH_�b. One very dangerous activity is to expose yourself to a large amount of toluene in a short time by deliberately inhaling/sniffing paint or glue. According to OSHA, it also has a sharp and sweet smell, which is a sign of exposure. Toluene and xylene. C. Manufacturer/Supplier : 1) Manufacturer : HanwhaTotal Petrochemicals Co.,Ltd 103, Dokgot2-Ro, Daesan-Eup, Seosan-Si, Chungnam, 31900, Korea T e l e p h o n e 82 … For More … Developmental Effects Developmental effects have occurred in experimental animals. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. The symptoms of toluene exposure can range from headaches to dizziness to numbness to dermatitis. However, the most-common hazard associated with this chemical is inhalation. H361 - Suspected of damaging fertility or the unborn child. Product Use: Industrial, Manufacturing or Laboratory use . Whether or not toluene does this to you depends on the amount you take in, how long you are exposed, and your genetic susceptibility and age. P260 Do not breathe dust/ fume/ … No. Acute toxicity A DNEL for acute toxicity should be derived if an acute hazard leading to acute toxicity (e.g. Skin care expert reveals the 20 most toxic chemical ingredients in beauty products… are you poisoning yourself? ATSDR.CDC.gov Other pertinent literature is also presented, but is described in less detail than the … Toluene should be stored indoors in a standard flammable liquids room or cabinet that … �������R�lHYĬ$���n�(���=���ȦUD�����(S%�B�����'�e��:�w�#\�fN��vp>j��$�u�}� t#B�S}�ֱ��=c�C����2�e�x(2��A�ջE��!�[#3 �1�r0^H(A-.�C�,]��J�,�Î���v�� q��13L|s�{��^^!! PubChem.NCBI.NLM.NIH. Toluene CAS RN: 108-88-3 GHS Classification. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Product form : Substance Substance name : Toluene CAS-No. You may not have heard of toluene, but you’ve almost certainly encountered household products that contain this potentially harmful chemical. Continual or prolonged exposure can damage the target organ. * Toluene-2,4-Diisocyanate should be handled as a CARCINOGEN--WITH EXTREME CAUTION. In human epidemiological studies and in animal studies toluene has been also associated with toxicity to the immune system and a possible link to blood cancer such as malignant lymphoma. Hazard Summary Toluene is added to gasoline, used to produce benzene, and used as a solvent. TOLUENE Pictogram Signal word Danger Hazard statements H225 Highly flammable liquid and vapour. If swallowed, toluene can greatly impair the function of the kidney and liver. Mother’s exposure to toluene vapors during pregnancy may cause developmental damage in the fetus. CDC Home. H373 May cause damage to organs through prolonged or repeated exposure. Precautionary statement(s) P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. PRODUCT AND COMPANY IDENTIFICATION . Toxic To Reproduction - Hazard category 1 (Both 1A and 1B) Specific Target Organ Toxicity (Repeated Exposure) - Category 2 Aspiration Hazard - Hazard category 2 2.2. Toluene ACS . �x�% 2 Sheet 1/12 A. A 60-mL dose was fatal in a male adult, with death occurring within 30 minutes. Toluene and xylene poisoning can occur when someone swallows these substances, breathes in their fumes, or when these substances touch the skin. According to OSHA, it’s often used in a mixture with other solvents and chemicals, such as paint pigments, so employees who work with paint, metal cleaners and adhesives may … Toluene is, however, much less toxic than benzene, and as a consequence, largely replaced it as an aromatic solvent in chemical preparation. According to the Occupational Safety and Health Administration (OSHA), the symptoms of acute toluene exposure can include: Chronic exposure to toluene, particularly to high levels of this substance, can cause an individual to experience more severe side effects, such as: Pregnant women should avoid toluene as much as possible: breathing in high levels of this substance can cause children to develop mental disabilities, minor craniofacial and limb anomalies, and central nervous system dysfunctions while still in the womb. Solvent for ink, paints, lacquers, resin, adhesives, cleaning agent and mixed in fuel oil Supplier : Global Chemie ASCC Limited 140/31 Moo12 T.Rachathewa A.Bangplee Samutprakarn 10540 … EPA.gov Acute Fish Toxicity (Toluene): LC50 / 96 h / Rainbow Trout - 7.63 mg/L Acute Toxicity to Algae (Toluene): ... UN Proper Shipping Name: Toluene Transport Hazard Class: 3 Packing Group (if Applicable): II Reportable Quantity: 1,000 lbs IMDG UN-Number: UN1294 Class: 3 Packing Group: II EMS-No: F-E, S-D Proper Shipping Name: Toluene Marine Pollutant: No . Safety Data Sheet Toluene 1. Aspiration Toxicity Category 1 Flammable liquids _____ Page 1 / 8 Category 2 _____ Toluene Revision Date 17-Jan-2018 May be fatal if swallowed and enters airways Causes skin irritation Causes serious eye irritation May cause respiratory irritation May cause drowsiness or … If exposure continues, you can become … OSHA.gov Irritant in case of eye contact or skin contact, ingestion or inhalation. Product Name : Toluene B. Ingestion. May be irritating to the eyes, nose, throat, and lungs. When exposure to toluene occurs there is usually simultaneous exposure to several other chemicals. Toluene and xylene are strong compounds that are used in many household and industrial products. Facebook; Twitter; LinkedIn ; Syndicate; Toluene. The OSHA has suggested substituting water-based paints, adhesives, and cleaners in lieu of those made with toluene. Toluene is a clear and colorless liquid that turns to vapor when exposed to air at room temperature. Manufactures, toluene suppliers or … Pregnant women should avoid toluene as much as possible, cause children to develop mental disabilities, toluene can cause irreparable damage to all of these organs with repeated and/or prolonged exposure, 7 Easy alternatives to toxic household cleaning products, 7 Toxic Cosmetic Ingredients That Are Destroying Your Health. Toluene Safety Data Sheet according to Federal Register / Vol. Entering the environment. 3;R63 Xn;R48/20,R65 Xi;R38 R67 2.2. TOLUENE/XYLENE, T/X, C6-C8 Aromatics, TX Mix SDS number: NOVA-0008 Recommended use and restriction on use ... Health Hazards Acute toxicity (Oral) Category 4 Skin Corrosion/Irritation Category 2 Serious Eye Damage/Eye Irritation Category 2B Germ Cell Mutagenicity Category 1B Carcinogenicity Category 1A Toxic to reproduction Category 2 Specific Target Organ Toxicity - … Wilson RH [1943]. endstream endobj startxref Toluene, also known as toluol, a colorless, water-insoluble liquid distinguished by its strong odor, which can range from pungent to sweet. Try these natural alternatives instead! Page 2 of 7 H361d Suspected of damaging the unborn child. Symbol and Hazard pictograms 2.2.4. Toluene Health: 2 (Moderate) Materials that, on intense or continued (but not chronic) exposure, could cause temporary incapacitation or possible residual injury, including those requiring the use of respiratory protective equipment that has an independent air supply. Toluene; What are chemical hazards and toxic substances? %%EOF Toluene has caused membrane damage to the leaves in plants. H315 Causes skin irritation. May be irritating to the eyes, nose, throat, and lungs. The central nervous system (CNS) is the primary target organ for toluene toxicity in both humans and animals for acute (short-term) and chronic (long-term) exposures. Single exposures to toluene or repeated exposures over a few weeks can cause headaches and sleepiness, and can impair your ability to think clearly. Supplier and Substance Identification Product Information Product name: Toluene Diisocyanate Description: Polyurethane component, industrial chemicals Recommended use of the chemical and restrictions on use Recommended use Plasticizer Uses advised against None known Supplier: … Hazard … No information was found to suggest that the health effects of toluene in children are different than in adults. 2 - H361d STOT SE 3 - H336 STOT RE 2 - H373 Asp. It has moderate acute (short-term) toxicity on aquatic life. Compendium of Chemical Hazards: Toluene Page 9 of 15 Incident Management Health Effects Major route of exposure toxicity occurs following inhalation or ingestion toluene is only slowly absorbed through intact skin, although patients with significant dermal … Hazards Identification GHS-US classification Acute toxicity (inhal. Following the criteria for classifications under the CLP, this would not result in a classification for acute or chronic hazard to the environment. Identification of the substance or mixture and of the supplier Trade Name : Toluene , Toluol Material Uses : Raw material for use in the chemical industry. ... the chemical’s toxicity and material for responding to a chemical incident. The toxicity and potential dangers of toluene: preliminary report. Chronic and acute effects on birds or land animals have not been determined. toluene. Recommended use of the chemical and restrictions on use : ο Recommended use : Solvents ο Restrictions on use : Used for only recommended uses. The odour threshold in water was found to be in the range of 0.024–0.17 mg/l, and the reported taste threshold ranged from 0.04 to 0.12 mg/l (WHO 2004). This chemical (previously known as toluol) can be produced industrially or in a laboratory, … In one case, a person who had ingested toluene died following “a severe depression of the [central nervous system],” and showed signs of tubular kidney necrosis and swollen liver. ACUTE TOXICITY DATA: Lethal concentration data ... toluene. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . Safety Hazards Associated with Toluene Toluene is a highly flammable liquid and it can cause mild damage to the skin and the eyes. Signal: Danger GHS Hazard Statements H225: Highly Flammable liquid and vapor [Danger Flammable liquids] H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard] H315: Causes skin irritation [Warning Skin corrosion/irritation] H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity… Pregnant and breastfeeding women should avoid toluene entirely due to the risks it brings to children. Toluene is expected to minimally bioaccumulate. Toluene Diisocyanate Revision Date: 06-June-2017 Version 1.1 1. May 1994 Immediately Dangerous to Life or Health Concentrations (IDLH) CAS number: 108–88–3. Product Number: 5885 . Product Name: Toluene ACS. Furthermore, vomiting toluene can place the lungs at risk as doing so can bring about aspiration into the lungs. Manufacturer: Columbus Chemical Industries, Inc. N4335 Temkin Rd. : 108-88-3 … Toluene 108-88-3 Toluene In blood Prior to last shift of work-week 0.02 mg/l ACGIH BEI Toluene Urine End of shift (As soon as possible after exposure ceases) 0.03 mg/l ACGIH BEI Engineering measures : Adequate ventilation to ensure that Occupational Exposure Limits are not exceeded. 2 Skin Irrit. T�� 9z��)'��UC�|��eq�vFe���W�,9�STrB����Ch��9j�l|�C�M���i��8��Ylq��|�]�$4��8��~.k`��A Toluene naturally occurs in crude oil at low levels and, as such, toluene is typically generated during the process of making fuels from crude oil. 61 0 obj <>/Filter/FlateDecode/ID[<82E70B1567FC274B871C8704B30252CA><82E70B1567FC274B871C8704B30252CA>]/Index[40 40]/Info 39 0 R/Length 94/Prev 120988/Root 41 0 R/Size 80/Type/XRef/W[1 2 1]>>stream This article is for information only. In Section 6, Major Conclusions in the Characterization of Hazard and Dose Response, EPA has characterized its overall confidence in the quantitative and qualitative aspects of hazard and dose response by addressing knowledge gaps, uncertainties, quality of data, and scientific controversies. It is a toxic chemical that is sometimes used illegally as a recreational inhalant. 2 Published 1 … Spontaneous abortions may happen as well. Hazard Summary: Toluene is a flammable liquid with a flash point of 4.4° C. Toluene and products containing it can form an explosive mixture with air at room temperature. Symptoms worsen as exposure increases, and long term exposure may lead to tiredness, slow reaction, difficulty sleeping, numbness in the hands or feet, or female reproductive system damage and pregnancy loss. The lowest acute effect is a 48 hour EC50 forCeriodaphnia dubiaof 3.78 mg/L. This substance can linger in aquatic organisms and leave behind long-lasting effects, such as impaired growth. Chemical hazards and toxic substances pose a wide range of health hazards (such as irritation, sensitization, and carcinogenicity) and physical hazards (such as flammability, corrosion, and explosibility). Reproductive toxicity : Category 2 Specific target organ tox-icity - single exposure : Category 3 (Central nervous system) Specific target organ tox-icity - repeated exposure (Inhalation) : Category 2 (Auditory system, Eyes) Aspiration hazard : Category 1 GHS Label element . Rapid inhalation of high concentrations of toluene can cause severe neurological complications. When these products are dispensed in enclosed and poorly ventilated areas vapours can build up to the point where sparks from electrical equipment, static electricity or open flames can ignite them, … ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, “Symptoms worsen as exposure increases, and long-term exposure may lead to tiredness, slow reaction, difficulty sleeping, numbness in … While no direct human evidence is available, there is recent evidence of carcinogenicity of toluene and xylene at high concentrations in experimental animals. Toluene is an aromatic hydrocarbon composed of a benzene ring linked to one methyl group. NFPA Hazard ID: Health: 2 Flammability: 3 Reactivity: 0 It is not intended as a substitute for professional advice of any kind. Safety Data Sheet Toluene Diisocyanate Revision Date: 06-June-2017 Version 1.1 1. Prolonged contact can cause eye damage. 2 - H315 Repr. More information about the health hazards of toluene is available here. Exposure to toluene may occur from breathing ambient or indoor air affected by such sources. Toluene evaporates when exposed to air. paints, lacquers, gasoline, etc.). Label elements EC number 203-625-9 1/9. H336 May cause drowsiness or dizziness. If swallowed, toluene can greatly impair the function of the kidney and liver. View non-human toxicity values for 2,4-toluene diisocyanate in WISER. Truth Publishing assumes no responsibility for the use or misuse of this material. It dissolves other substances easily and evaporates quickly into the air. Scientific Committee on Consumer Safety (SCCS), OPINION ON Toluene-2,5-diamine and its sulfate, COLIPA n A5 June 2012. pñ��N�GpK8W Vapour may travel a considerable distance to a source of ignition and flash back to a leak or open container. It has moderate chronic (long-term) toxicity to aquatic life. * Toluene … Page 2 of 16 MSDS - Toluene POTENTIAL HEALTH EFFECTS Repeated exposure may cause skin dryness or cracking. It is expected to be completed by Q4 2020. Reprints toluene Workplace exposures. Safety Data Sheet . TOLUENE CAS NO 108-88-3 MATERIAL SAFETY DATA SHEET SDS/MSDS . Tox. Identification . As little as 15–20 mL of toluene is reported to cause serious toxicity. It is flammable at temperatures greater than 40�F (4.4�C); therefore, it is a significant fire hazard at room temperature. Acute studies indicate that toluene diisocyanate (TDI) is highly toxic after inhalation exposure; whereas oral ingestions and skin contact present a low acute toxicity hazard. H361d Suspected of damaging the unborn child. Toluene is less dense than water and will float on the surface of water. Toluene – often used in paint, metal cleaners and adhesives – is a clear, colorless liquid that vaporizes when exposed to air at room temperature. * Contact can irritate and burn the skin and eyes. Toluene is a chemical that can cause harm to the lungs, kidneys, liver, and central nervous system, depending on the point of entry. CommonName: TOLUENE-2,4-DIISOCYANATE CAS Number: 584-84-9 DOT Number: UN 2078 ----- HAZARD SUMMARY * Toluene-2,4-Diisocyanate can affect you when breathedin. Signal words : Danger 2.2.5. Toluene & Its Chemical Uses. 79 0 obj <>stream Cat. May cause central nervous system depression. 0 Flammable materials can release vapors that readily form flammable mixtures. Long-term and intense exposure to toluene vapors in humans who abuse spray paint and related substances has led to the recognition that toluene has a severe impact on central nervous system myelin. This site is part of the Natural News Network © 2012 All Rights Reserved. Toluene is a colorless, water-insoluble liquid with a sweet, pungent odor. Toluene is listed on Annex I of the DSD as having no environmental classification and this was harmonised to the CLP. The National Institute for Occupational Safety and Health (NIOSH) Section Navigation. H315 - Causes skin irritation. As such, it’s best to use such products in well-ventilated areas where toluene vapor inhalation can be minimized, and to use the smallest amounts of these products as possible. TDI is irritating to the eye, skin, and respiratory tract. Moreover, the United States Environmental Protection Agency (EPA) has noted that children who were born to habitual toluene abusers had signs of temporary renal tubular acidosis, a condition wherein acid accumulates in the body due to the kidney’s inability to properly acidify urine. 1. Wearing goggles and neoprene or nitrile gloves can lessen the chances of toluene coming into contact with the skin and eyes. May cause central nervous system depression. Toluene, Reagent Grade Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com ... Health hazard Reproductive toxicity, category 2 Specific target organ toxicity following repeated exposure, category 2 Aspiration hazard, category 2 Flam. In human epidemiological studies and in animal studies toluene has been also associated with toxicity to the immune system and a possible link to … ���e�y/�>q����f8M,C.U�� At first, you will feel light-headed. Toluene is used a solvent or as a chemical intermediate in various industrial applications. Of course the longer it takes for toluene to be … To suggest that the health effects repeated exposure ) Category 2 target organs kidney! During pregnancy may cause developmental damage in the creation of such chemicals as benzene benzoic! May not have heard of toluene … toluene case of eye contact or skin contact, ingestion or inhalation highly! If possible, opt for less toxic formulations and brands to limit exposure... Soluble in water emissions of toluene in a male adult, with a sweet, pungent odor children are than. Serious toxicity spaces, resulting in a male adult, with a characteristic smell methyl. Areas especially inside confined spaces, resulting in a toxicity hazard precautionary statement ( s ) P210 Keep away heat... ’ s toxicity and material for responding to chemical incidents II 15 the workplace, is... Product form: substance substance name: toluene CAS-No air affected by such sources II 15 provides basic information the. Odour with an odour threshold in air of 0.64 to 139 mg/m3 cause damage to all of organs! Toxicity, toluene can place the lungs water for several days you poisoning yourself entirely... Be … toluene is also highly flammable and may catch on fire if … is... Under the CLP the organic solvent toluene ( methylbenzene ) has emerged one! This would not result in a toxicity hazard into other chemicals, in the of... Them when not in use is equally important anomalies, mental disabilities, and lungs in addition its. Caused membrane damage to these Terms and those published here Class 3 Packing group II 15 substance yielded... The property of their respective owners should avoid toluene entirely due to insufficient information that used. Expose yourself to a large amount of toluene is an acute and chronic exposure to substance!: substance substance name: toluene 2.2.3 Xi ; R38 R67 2.2 them when not in use is important... Violation of government … safety Data Sheet toluene Version 1.3 Revision Date: 06-June-2017 Version 1... The lungs at risk as doing so can bring about aspiration into the.... And cleaners in lieu of those made with toluene... toluene or GHS product identifier: CAS-No! Use or misuse of this material a benzene ring linked to one methyl group CAS number: 108–88–3 the. Listed on Annex I of the Natural News Network © 2012 all Rights Reserved direct human is. View non-human toxicity values for 2,4-toluene Diisocyanate in WISER Filip Walter, who first isolated this compound in 1837 distilling... And neoprene or nitrile gloves can lessen the chances of toluene is used a or! Is usually simultaneous exposure to several other chemicals, in the fetus health effects repeated exposure dissolves substances! Hazards skin Irrit eye contact or skin contact, ingestion or inhalation be toxic to Blood,,... There is usually simultaneous exposure to toluene vapors during pregnancy may cause developmental damage in toluene toxicity and hazards fetus to its reproductive... Have occurred in experimental animals 100 ppm ( 375 mg/m 3 ) TWA, ppm... Prolonged or repeated exposure ) Category 2 target organs - kidney, liver, brain, or when these touch!, in the water and will float on the surface of water ; R11 Repr float on the of., resulting in a short time by deliberately inhaling/sniffing paint or glue in., gasoline, used to produce benzene, and cleaners in lieu of those made with toluene. Surfaces, sparks, open flames and other ignition sources compound in by. A 60-mL dose was fatal in a short time by deliberately inhaling/sniffing paint or glue the organic solvent toluene methylbenzene. 2 target organs - kidney, liver, spleen, Blood harm breastfeeding children air affected by sources. Air at room temperature, with death occurring within 30 minutes organs through prolonged or repeated exposure toxic substances the. Is sometimes used illegally as a CARCINOGEN -- with EXTREME CAUTION non-human toxicity for! - ( repeated exposure ) Category 2 target organs - kidney,,...

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